| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Racine Horlick (NC) | 35 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 6 | |
| 8/26/2022 | 2 | Greendale (NC) | 55 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 0 | |
| 9/2/2022 | 3 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 26 | Milwaukee Riverside/Golda Meir | 28 | |
| 9/8/2022 | 4 | Milwaukee Bradley Tech/Milw Arts | 0 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 42 | |
| 9/16/2022 | 5 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 25 | Milwaukee Bay View/Milw Lifelong Learning | 0 | |
| 9/22/2022 | 6 | Milwaukee King | 0 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 13 | |
| 9/30/2022 | 7 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 52 | Milwaukee Reagan | 14 | |
| 10/6/2022 | 8 | Milwaukee Hamilton/Audubon Tech | 20 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 32 | |
| 10/13/2022 | 9 | Milwaukee Vincent/Destiny | 6 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 40 | |