| Date | Week | Home | Score | Away | Score | |
| 8/25/2022 | 2 | Milwaukee South | 6 | Milwaukee Vincent/Destiny | 36 | |
| 9/1/2022 | 3 | Milwaukee Vincent/Destiny | 36 | Milwaukee Washington/Fuller Collegiate | 6 | |
| 9/9/2022 | 4 | Milwaukee Pulaski/Carmen South/Carmen SE | 18 | Milwaukee Vincent/Destiny | 20 | |
| 9/15/2022 | 5 | Milwaukee Vincent/Destiny | 68 | Obama SCTE | 0 | |
| 9/23/2022 | 6 | Milwaukee Madison | 14 | Milwaukee Vincent/Destiny | 56 | |
| 10/1/2022 | 7 | Milwaukee Vincent/Destiny | 20 | Milwaukee Hamilton/Audubon Tech (NC) | 24 | |
| 10/7/2022 | 8 | Milwaukee Vincent/Destiny | 42 | Milwaukee North | 0 | |
| 10/13/2022 | 9 | Milwaukee Vincent/Destiny | 6 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 40 | |