| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Poynette (NC) | 8 | Cambria-Friesland | 16 | |
| 8/25/2022 | 2 | Cambria-Friesland | 46 | Dodgeland (NC) | 0 | |
| 9/2/2022 | 3 | Cambria-Friesland | 28 | Lourdes Academy | 7 | |
| 9/9/2022 | 4 | Johnson Creek | 22 | Cambria-Friesland | 28 | |
| 9/16/2022 | 5 | Cambria-Friesland | 28 | Deerfield | 27 | |
| 9/23/2022 | 6 | Cambria-Friesland | 20 | Randolph | 16 | |
| 9/30/2022 | 7 | Pardeeville | 20 | Cambria-Friesland | 24 | |
| 10/7/2022 | 8 | Cambria-Friesland | 22 | Fall River/Rio | 18 | |
| 10/14/2022 | 9 | St. John's NW Academies | 0 | Cambria-Friesland | 1 | |
| 10/14/2022 | 9 | *Cambria-Friesland | 32 | *Kenosha Christian Life (NC) | 26 | |