| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Colby | 43 | Neillsville/Granton (NC) | 8 | |
| 8/26/2022 | 2 | Spencer/Columbus Catholic (NC) | 0 | Colby | 41 | |
| 9/2/2022 | 3 | Iola-Scandinavia | 20 | Colby | 56 | |
| 9/9/2022 | 4 | Colby | 48 | Loyal | 8 | |
| 9/16/2022 | 5 | Edgar | 6 | Colby | 32 | |
| 9/23/2022 | 6 | Colby | 21 | Pittsville | 6 | |
| 9/30/2022 | 7 | Marathon | 14 | Colby | 35 | |
| 10/7/2022 | 8 | Colby | 55 | Abbotsford | 14 | |
| 10/14/2022 | 9 | Colby | 14 | Auburndale | 20 | |