| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Osceola | 26 | Hayward/Lac Courte Oreilles (NC) | 0 | |
| 8/26/2022 | 2 | Mondovi (NC) | 40 | Osceola | 0 | |
| 9/2/2022 | 3 | Prescott | 43 | Osceola | 23 | |
| 9/9/2022 | 4 | Osceola | 0 | St. Croix Central | 28 | |
| 9/16/2022 | 5 | Amery | 28 | Osceola | 34 | |
| 9/23/2022 | 6 | Osceola | 6 | Baldwin-Woodville | 27 | |
| 9/30/2022 | 7 | Ellsworth | 42 | Osceola | 13 | |
| 10/7/2022 | 8 | Osceola | 13 | Rice Lake | 42 | |
| 10/14/2022 | 9 | Osceola | 15 | Somerset | 14 | |