| Date | Week | Home | Score | Away | Score | |
| 8/20/2022 | 1 | Aquinas (NC) | 36 | Prairie du Chien | 14 | |
| 8/26/2022 | 2 | Edgewood (NC) | 47 | Prairie du Chien | 13 | |
| 9/2/2022 | 3 | Lancaster | 29 | Prairie du Chien | 33 | |
| 9/9/2022 | 4 | Prairie du Chien | 43 | Richland Center | 0 | |
| 9/16/2022 | 5 | Platteville | 14 | Prairie du Chien | 23 | |
| 9/23/2022 | 6 | Prairie du Chien | 53 | River Valley | 14 | |
| 9/30/2022 | 7 | Dodgeville | 14 | Prairie du Chien | 56 | |
| 10/7/2022 | 8 | Prairie du Chien | 30 | Brodhead/Juda | 21 | |
| 10/14/2022 | 9 | Montello/Green Lake/Princeton | 0 | Prairie du Chien | 1 | |