| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Saint Francis | 6 | Saint Thomas More (NC) | 22 | |
| 8/26/2022 | 2 | Turner (NC) | 42 | Saint Francis | 8 | |
| 9/2/2022 | 3 | Dominican | 0 | Saint Francis | 1 | |
| 9/10/2022 | 4 | Living Word Lutheran | 28 | Saint Francis | 74 | |
| 9/16/2022 | 5 | Saint Francis | 12 | Kenosha St. Joseph Catholic | 47 | |
| 9/23/2022 | 6 | Racine Lutheran | 41 | Saint Francis | 14 | |
| 9/30/2022 | 7 | Saint Francis | 43 | Brookfield Academy | 27 | |
| 10/7/2022 | 8 | Kenosha Christian Life | 20 | Saint Francis | 28 | |
| 10/14/2022 | 9 | Saint Francis | 7 | Catholic Central | 23 | |