| Date | Week | Home | Score | Away | Score | |
| 8/22/2025 | 1 | Southwestern/East Dubuque, IL | 19 | Black Hawk/Warren, IL (NC) | 24 | |
| 8/29/2025 | 2 | Boscobel (NC) | 0 | Southwestern/East Dubuque, IL | 48 | |
| 9/5/2025 | 3 | Fennimore | 41 | Southwestern/East Dubuque, IL | 14 | |
| 9/12/2025 | 4 | Southwestern/East Dubuque, IL | 44 | Darlington | 65 | |
| 9/19/2025 | 5 | Cuba City | 28 | Southwestern/East Dubuque, IL | 16 | |
| 9/19/2025 | 5 | Cuba City | | Southwestern/East Dubuque, IL | | |
| 9/26/2025 | 6 | Southwestern/East Dubuque, IL | | Belleville | | |
| 9/26/2025 | 6 | Southwestern/East Dubuque, IL | 35 | Belleville | 49 | |
| 10/3/2025 | 7 | Mineral Point | 24 | Southwestern/East Dubuque, IL | 12 | |
| 10/3/2025 | 7 | Mineral Point | | Southwestern/East Dubuque, IL | | |
| 10/10/2025 | 8 | Fulton, IL (NC) | 56 | *Southwestern/East Dubuque, IL | 40 | |
| 10/10/2025 | 8 | Abundant Life Christian/Saint Ambrose | 0 | Southwestern/East Dubuque, IL | 1 | |
| 10/17/2025 | 9 | Southwestern/East Dubuque, IL | | Benton/Scales Mound (IL)/Shullsburg | | |
| 10/17/2025 | 9 | Southwestern/East Dubuque, IL | 22 | Benton/Scales Mound (IL)/Shullsburg | 21 | 1OT |