| Date | Week | Home | Score | Away | Score | |
| 8/22/2025 | 1 | Auburndale (NC) | 35 | Spencer/Columbus Catholic | 27 | |
| 8/29/2025 | 2 | Spencer/Columbus Catholic | 49 | Pittsville (NC) | 34 | |
| 9/5/2025 | 3 | Stratford | 27 | Spencer/Columbus Catholic | 15 | |
| 9/12/2025 | 4 | Spencer/Columbus Catholic | 15 | Weyauwega-Fremont | 29 | |
| 9/19/2025 | 5 | Spencer/Columbus Catholic | 27 | Wittenberg-Birnamwood | 8 | |
| 9/26/2025 | 6 | Amherst | | Spencer/Columbus Catholic | | |
| 9/26/2025 | 6 | Amherst | 35 | Spencer/Columbus Catholic | 22 | |
| 10/3/2025 | 7 | Loyal/Greenwood | 16 | Spencer/Columbus Catholic | 26 | |
| 10/10/2025 | 8 | Spencer/Columbus Catholic | | Colby | | |
| 10/10/2025 | 8 | Spencer/Columbus Catholic | 43 | Colby | 12 | |
| 10/17/2025 | 9 | Marathon | | Spencer/Columbus Catholic | | |
| 10/17/2025 | 9 | Marathon | 6 | Spencer/Columbus Catholic | 14 | |